B5 is the one that's closest to a 'true' space opera, in the sense that there was a massive overarching storyline that encompassed the whole 5 seasons - and by that I don't mean the Enterprise 'boldly going' anywhere - the only Trek season to have a plot arc like B5 is DS9 - S1, TBG, Voyager all had an overall theme, but not a defining plot arc. Enterprise could never decide whether it was one or the other which was it's main problem.
Andromeda - references philosophy, features hi-tech post-war 'find the goodies' stuff, and is the only US TV series here to really feature AI n any meaningful (abnd sexy) way. Arguably the ORAC, the LIberator and Slave were all AIs but Dromy is AI in the Iain M Banks sense that it's a ship with a mind (but not like the Lexx which AFAIK is some kind of bio-mech creature, and it requires Pilot to fly it...or is that Farscape?)
Would have been Gene Rodenberry's most amazing creation - the Andromeda universe is (IMO) far more sci-fi that Trek. Unfortunately, budgets and Kevin Sorbo put paid to any chance it had of getting anywhere. My favourite eps would have to be the one about the battle that started the galactic civil war off and where the pilot chick uses some serious ass drugs to try and fly the Andromeda to some mythical old tech planet (sorry, no ep guide to hand!!)
I'd go for B5 and Andromeda, with honourable mentions to Andromeda (for concept rather than execution) and Farscape. Trek is just in a class of it's own.
Rommie, avatar of starship The Andromeda Ascendant