Jason Lutes Berlin series is great, first two volumes out already - Berlin - City of Smoke and Berlin - City of Stone. Starts in 1928. Main characters are a female artist and a male journalist. Black and white drawings.
Also Chester Brown is great for autobiographical comics, check out I Never Liked You, The Playboy and The Little Man (Short Stories). Another vote for From Hell and Maus and Persopolis.
I'm also massively into French and Belgian comic artists, but their stuff is really hard to get hold of in English. I recommend - Yslaire - From Cloud 99. Loisel's Peter Pan series is beautiful. Franquin is great, and was mentioned here before.
For a real American classic, beautifully drawn, Little Nemo by Winsor McCay about a boy whose dreams take him to a magic land.
Joe Sacco's Palestine is good too.