Although I had seen a review of the Clip noting that it could connect to Macs, there was no indication on the packaging that it was Mac-compatible; the box listed system requirements as Windows XP2 and Windows Media Player 10. Luckily, I could have brought it back for a refund if it hadn't worked for me.
The Clip comes with a short USB cable; when it was connected to my Mac, it promptly appeared as an external drive - the Clip's 1" screen showed that it was connected and charging. Double-clicking the drive icon on my Mac showed folders labeled Music and Audible (for Audible book recordings). It was no sweat to copy album folders from my Mac into the Music folder.
The real test, of course, is whether the music works. The Clip's packaging promises support for MP3 and both protected and unprotected Windows Media music files, along with Audible book files. There's no support for Apple's AAC file format, used by default when you rip CDs to iTunes or download copy-protected music from the iTunes Store.
Because I routinely set iTunes to rip CDs to MP3, the music files that I copied over to the Clip played without problem, showing artist and album information on its small screen.
http://lowendmac.com/zisman/08az/sansa-clip-mac.html