Ike Turner's actual music career began in earnest in the late-1940s where he formed a group whom he christened The Kings of Rhythm. In 1951, the band recorded what historians have debated as "the first rock and roll record"[4] with "Rocket 88", listed on the charts as Jackie Brenston and His Delta Cats. Brenston was both the band's saxophonist and the leading vocalist of the song and Turner was the original writer though credits initially stated that Brenston had written it also. The song was one of the first examples of guitar distortion, which happened by accident when one of the amplifiers dropped before the recording. Ike and the Kings of Rhythm settled into local fame in St. Louis where the band locally recorded for a St. Louis label and even appeared on local television shows. Throughout this early period, Turner became a recording scout and A&R man for independent record companies including Sun Records - where "Rocket 88" was recorded, helping the likes of Howlin' Wolf, Sonny Boy Williamson, Elmore James and Otis Rush get signed. He also became a sideman playing guitar for these blues acts and more. Musically, Turner was known for his hard-hitting guitar style. He was known to put the whammy bar of his Fender Stratocaster to frequent use.
Turner's music career changed drastically after meeting a teenage singer from Nutbush, Tennessee, named Anna Mae Bullock, who demandingly grabbed a microphone during a singing session at one of St. Louis' nightspots and sang a BB King song in her now-trademark throated raspy vocals.